5-HT3 receptor antagonists vs traditional agents for the prophylaxis of postoperative nausea and vomiting
ثبت نشده
چکیده
Searching MEDLINE, EMBASE, and Pre-MEDLINE were searched from 1966 to October 1999 for articles published in the English language. References from retrieved articles were also manually searched. The search terms included 'nausea', 'vomiting', 'emesis', 'postoperative', 'surgery', 'ondansetron', 'granisetron', 'tropisetron', 'dolasetron', 'metoclopramide', 'droperidol', 'prochlorperazine', 'perphenazine', 'dimenhydrinate' and 'cyclizine'. Trials published more than once, data published in only abstract form, and unpublished data were excluded.
منابع مشابه
5-HT3 receptor antagonists vs traditional agents for the prophylaxis of postoperative nausea and vomiting.
PURPOSE Numerous antiemetics have been studied for the prevention of postoperative nausea and vomiting (PONV) including traditional agents (metoclopramide, perphenazine, prochlorperazine, cyclizine and droperidol) and the 5-HT3 receptor antagonists (ondansetron, dolasetron, granisetron and tropisetron). The results have been divergent and inconsistent. The purpose of this quantitative systemati...
متن کامل5-HT3 receptor antagonists vs traditional agents for the prophylaxis of postoperative nausea and vomiting
Searching MEDLINE, EMBASE, and Pre-MEDLINE were searched from 1966 to October 1999 for articles published in the English language. References from retrieved articles were also manually searched. The search terms included 'nausea', 'vomiting', 'emesis', 'postoperative', 'surgery', 'ondansetron', 'granisetron', 'tropisetron', 'dolasetron', 'metoclopramide', 'droperidol', 'prochlorperazine', 'perp...
متن کامل5-HT3 receptor antagonists for the treatment of nausea/vomiting.
It is well appreciated that a number of things (e.g., various insults, chemotherapeutic agents, radiation) may lead to the release of serotonin from the enterochromaffin of the gastrointestinal tract. Released serotonin may then bind to certain 5-HT3 receptors and promote nausea/vomiting. 5-HT3 receptor antagonists may ameliorate nausea/vomiting in a number of circumstances and have been utiliz...
متن کامل[Prevention and treatment of postoperative nausea and vomiting with 5-HT3-receptor blockers].
Since there continues to be a high incidence of postoperative nausea and vomiting associated with many types of surgery, and the standard antiemetics often do not achieve satisfactory results, there have been attempts to use the 5-HT3 antagonists. This group of substances is relatively new, but has already been used successfully as an antiemetic during chemotherapy. To date, results are on hand...
متن کاملThe efficacy and cost-effectiveness of prophylactic 5-hydroxytryptamine3 receptor antagonists: tropisetron, ondansetron and dolasetron.
There are currently three 5-hydroxytryptamine3 (5-HT3) receptor antagonists available in Australia. In this randomized, double-blind, parallel group study the prophylactic antiemetic effect of a single dose of tropisetron 2 mg, ondansetron 4 mg or dolasetron 12.5 mg was compared after major gynaecological surgery. One hundred and eighteen patients (group T n = 42; group O n = 36; group D n = 40...
متن کامل